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GENETIC KNOCKOUT OF CATHEPSIN D USING ZINC-FINGER NUCLEASES DELIVERED BY AAV VECTORS.

abril 26, 2021

GENETIC KNOCKOUT OF CATHEPSIN D USING ZINC-FINGER NUCLEASES DELIVERED BY AAV VECTORS. descargar PDF gratis

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genetic knockout of cathepsin d using zinc-finger nucleases delivered by aav vectors.-9783656525035

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Sinopsis de GENETIC KNOCKOUT OF CATHEPSIN D USING ZINC-FINGER NUCLEASES DELIVERED BY AAV VECTORS.

Project Report from the year 2013 in the subject Biology – Neurobiology, grade: 1.0, University of Göttingen, language: English, abstract: Genetic engineering is known as a powerful technique for basic research and clinical applications. Recent progress in development of zinc-finger nucleases (ZFNs), which combine the DNA cleavage ability of Fok1 restriction enzyme with highly specific recognition properties of zinc-finger motifs, allows to improve efficiency and to broaden the field of use of genome editing. Here, we demonstrate our initial results in generating novel tools for Cathepsin D gene knockout in neurons based on ZFNs technology and mediated by adeno-associated virus (AAV) vectors. Pairs of AAV-ZFNs were produced and demonstrated the robust expression of nucleases in neuronal cell culture. Observed toxicity most likely was associated with heterodimerization but not homodimerization of ZFNs cytotoxicity was greatly reduced when ZFN were provided at lower concentrations. Future studies evaluating efficiency of Ctsd knockout, off-target effects on molecular level and long-term outcomes in vivo can be performed.
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